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A comparative study of electroacupuncture at Zhongliao (BL33) and other acupoints for overactive bladder symptoms

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《医学前沿（英文）》 2017年 第11卷 第1期   页码 129-136 doi: 10.1007/s11684-016-0491-6

摘要：

Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detecting urodynamics in eight groups: no intervention group, D-BL33 group (deep needling at BL33), S-BL33 group (shallow needling at BL33), non-acupoint group (needling at the non-acupoint next to BL33), Weizhong (BL40) group, Sanyinjiao (SP6) group, Tongtian (BL7) group, and Hegu (LI4) group. Results revealed that EA at BL33 with deep needling, BL40, and SP6 prolonged the intercontraction interval (ICI) of rats with OAB (P=0.001, P=0.005, P=0.046, respectively, post-treatment vs. post-modeling). Furthermore, the change in ICI from post-modeling in the D-BL33 group was significantly greater than those of the no intervention and other EA groups (all P<0.01). Significantly shortened vesical micturition time (VMT) and elevated maximum detrusor pressure (MDP) were also observed in the D-BL33 group (P=0.017 and P=0.024, respectively, post-treatment vs. post-modeling). However, no statistically significant differences in the changes of VMT and MDP from post-modeling were observed between D-BL33 and the other EA groups. In conclusion, EA at BL33 with deep needling may inhibit acetic-acid-induced OAB more effectively.

关键词： overactive bladder     electroacupuncture     acupuncture points    

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Policy entry points for facilitating a transition towards a low-carbon electricity future

《工程管理前沿（英文）》   页码 462-472 doi: 10.1007/s42524-022-0214-4

摘要： This study extends the ambit of the debate on electricity transition by specifically identifying possible policy entry points through which transformative and enduring changes can be made in the electricity and socio–economic systems to facilitate the transition process. Guided by the “essence” of the multi-level perspective — a prominent framework for the study of energy transition, four such entry points have been identified: 1) destabilising the dominant, fossil fuel-based electricity regime to create room for renewable technologies to break through; 2) reconfiguring the electricity regime, which encompasses technology, short-term operational practices and long-term planning processes, to improve flexibility for accommodating large outputs from variable renewable sources whilst maintaining supply security; 3) addressing the impact of coal power phase-out on coal mining regions in terms of economic development and jobs; and 4) facilitating a shift in transition governance towards a learning-based, reflexive process. Specific areas for policy interventions within each of these entry points have also been discussed in the paper.

关键词： electricity transition     multi-level perspective     policy entry points    

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Acupuncture for the management of dry eye disease

《医学前沿（英文）》 2022年 第16卷 第6期   页码 975-983 doi: 10.1007/s11684-022-0923-4

摘要： The effectiveness of using acupuncture for dry eye disease (DED) is controversial. Thus, this systematic review investigated the effectiveness and feasibility of using acupuncture for DED in accordance with the 2020 PRISMA statement. The outcomes of interests were (1) to evaluate the efficacy of acupuncture in improving the ocular surface disease index (OSDI), Schirmer I test score, and tear breakup time from baseline to the last follow-up; (2) to determine possible complications of using acupuncture; and (3) to investigate the superiority of acupuncture over other commonly used treatments for DED. Data from 394 patients were collected. Results showed that acupuncture significantly prolonged the tear breakup time (P < 0.0001), significantly increased the Schirmer I test score ( P < 0.0001), and significantly reduced the OSDI ( P < 0.0001) from baseline to the last follow-up. Compared with the control group, the acupuncture group had significantly greater Schirmer I test score ( P < 0.0001), significantly longer tear breakup time ( P = 0.0004), and significantly lower OSDI (P = 0.002). These results suggest that acupuncture is effective and feasible in improving symptoms and signs of DED. No severe adverse effects of acupuncture were observed.

关键词： dry eye disease     xerophthalmus     acupuncture    

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Effects and mechanisms of acupuncture on women related health

《医学前沿（英文）》 doi: 10.1007/s11684-023-1051-5

摘要： Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when socioeconomic status is ignored. Women’s health has become a major public health concern, for those women from developing countries are still struggling with infectious and labor-related diseases, and their counterparts in developed countries are suffering from physical and psychological disorders. In recent years, complementary and alternative medicine has attracted wide attentions with regards to maintaining women’s health. Acupuncture, a crucial component of traditional Chinese medicine, has been used to treat many obstetric and gynecological diseases for thousands of years due to its analgesic and anti-inflammatory effects and its effects on stimulating the sympathetic/parasympathetic nervous system. To fully understand the mechanism through which acupuncture exerts its effects in these diseases would significantly extend the list of available interventions and would allow for more reasonable advice to be given to general practitioners. Therefore, by searching PubMed and CNKI regarding the use of acupuncture in treating obstetric and gynecological diseases, we aimed to summarize the proven evidence of using acupuncture in maintaining women’s health by considering both its effectiveness and the underlying mechanisms behind its effects.

关键词： acupuncture     women health     clinical efficacy     mechanism    

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Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking

Xuqiang Wei, Baoyan Liu

《医学前沿（英文）》 2021年 第15卷 第5期   页码 767-775 doi: 10.1007/s11684-020-0785-6

摘要： Acupuncture is a promising treatment for relieving pain and improving lower back function in clinical practice. However, evidence from randomized clinical trials (RCTs) remains controversial. Most RCTs conclude that acupuncture procedures for chronic low back pain (CLBP) had no significant difference in efficacy and belonged to placebo. We carefully reviewed and analyzed the methodology and implementation of sham acupuncture in RCTs. Controversial evidence of acupuncture for CLBP is only a microcosm of the evaluation methodological limitation of acupuncture. Inappropriate selection of sham acupuncture controls, rigorous RCT research models, and incorrect interpretation of results may contribute to negative evidence. Evaluating and disregarding the holistic efficacy of acupuncture with an explanatory RCT model based on evaluation drugs may be unwise. Moreover, sham acupuncture is often proven to be non-inert, unreasonable, and with low fidelity. Pitfalls of the explanatory RCT model and sham acupuncture design should be avoided. Establishing a new evaluation system that is in line with the clinical characteristics of acupuncture and obtaining high-quality evidence are difficult but promising tasks.

关键词： chronic low back pain     sham acupuncture     acupuncture     methodology     therapeutic evaluation    

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Assessment, Development, and Evaluation (GRADE) to the guideline development for clinical practice with acupuncture

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 590-594 doi: 10.1007/s11684-017-0537-4

摘要：

Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and limitations of the GRADE approach in the guideline development for acupuncture and moxibustion and propose some solutions to these limitations. Scientific advantages of rating the quality of evidence, outcome-centric direction, overall progression to develop recommendations, and strength of recommendations providing specific clinical guidance are the advantages of GRADE. The limitations of GRADE in the development of guidelines for acupuncture and moxibustion include rating the quality of evidence for ancient literature and literature on famous traditional Chinese medicine experts’ experiences and specific guidelines for formulating recommendations from evidence. In the guideline development for clinical practice with acupuncture and moxibustion, we suggest that a specific method should be explored based on the GRADE approach and the characteristics of acupuncture therapy.

关键词： guideline     acupuncture     GRADE    

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Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic

《医学前沿（英文）》   页码 993-1005 doi: 10.1007/s11684-023-0989-7

摘要： Migraine is one of the most prevalent and disabling neurological disease, but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects. Acupuncture is a promising complementary therapy, but further clinical evidence is needed. The influence of acupuncture on migraine is not an immediate effect, and its mechanism remains unclear. This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved. A randomized controlled trial was performed among 10 normal controls and 38 migraineurs. The migraineurs were divided into blank control, sham acupuncture, and acupuncture groups. Patients were subjected to two courses of treatment, and each treatment lasted for 5 days, with an interval of 1 day between the two courses. The effectiveness of treatment was evaluated using pain questionnaire. The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced by treatments. Blood plasma was collected for metabolomics and proteomics studies. Correlation and mediation analyses were performed to investigate the interaction between clinical, fMRI and omics changes. Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect, affected brain regions, and signaling pathways. The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress, reversal of brain energy imbalance, and regulation of inflammation. The brain regions of migraineurs affected by acupuncture include the lingual gyrus, default mode network, and cerebellum. The effect of acupuncture on patients’ metabolites/proteins may precede that of the brain.

关键词： acupuncture     migraine     fMRI     metabolome     proteome    

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Finding buckling points for nonlinear structures by dynamic relaxation scheme

Mohammad REZAIEE-PAJAND, Hossein ESTIRI

《结构与土木工程前沿（英文）》 2020年 第14卷 第1期   页码 23-61 doi: 10.1007/s11709-019-0549-z

摘要： Dynamic Relaxation Method (DRM) is an explicit approach for solving the simultaneous systems of equations. In this tactic, the fictitious mass and damping are added to the static governing equations, and an artificial dynamic system is constructed. By using DRM for nonlinear analysis, the structural static equilibrium path is obtained. This outcome is extremely valuable, since it leads to the behavior of structures. Among the finding related to the structural static path are the critical and buckling points for nonlinear structures. In this paper, a new way for calculating the load factor is proposed by setting the external work zero. Mixing the dynamic relaxation scheme with external work technique has not been formulated so far. In all incremental-iterative methods, the load factor increment sign should be determinated by extra calculations. This sign leads to increase or decrease of the load increment. It is worth emphasizing that sign of the load factor increment changes at the load limit points. Therefore, the sign determinations are required in the common work control methods. These disadvantages are eliminated in the proposed algorithm. In fact, the suggested load factor depends only on the Dynamic Relaxation (DR) fictitious parameters. Besides, all DR calculations are performed via vector operation. Moreover, the load factor is calculated only by one formula, and it has the same relation in the all solution processes. In contrast to the arc length techniques, which requires the sign determined, the proposed scheme does not need any sign finding. It is shown that author’s technique is quicker than the other dynamic relaxation strategies. To prove the capability and efficiency of the presented scheme, several numerical tests are performed. The results indicate that the suggested approach can trace the complex structural static paths, even in the snap-back and snap-through parts.

关键词： load factor     external work     dynamic relaxation     static equilibrium path     large displacement    

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Mechanism of acupuncture regulating visceral sensation and mobility

Peijing Rong, Bing Zhu, Yuqing Li, Xinyan Gao, Hui Ben, Yanhua Li, Liang Li, Wei He, Rupeng Liu, Lingling Yu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 151-156 doi: 10.1007/s11684-011-0129-7

摘要： Chinese ancient medical scientists have long focused on the internal and external contacts between acupoints on the surface of the body and the viscera. The Miraculous Pivot (it is one of the earliest medical classics in China) stated, “Twelve regular channels belong to the organs internally, and connect to the extremities and joints externally.” Traditional Chinese medicine considers acupoints as defined areas where the Qi of viscera and meridians are transfused. These include the reaction points of visceral diseases on the body surface as well as the acupuncture trigger points that promote the flow of Qi and blood, and regulate visceral function. Chinese ancient medical scientists classified the specificity of the main acupoints in the body based on the meridian doctrine, which has been instructing clinical application for about 2000 years. Laws on the domino effect of acupoints have mainly focused on conclusions to clinical experiences. Indications of some acupoints exceed the practical paradigm since the excessive extension occurred during theory derivation. The current research direction on acupuncture focuses on three aspects: the effectiveness of acupuncture and moxibustion; the relevances and associations between meridians and viscera; and the physical and chemical properties and relevant physical basis of acupoints. The relevance between meridians and viscera is the central theory in the meridian doctrine, and acupoints are regarded as an important link in the relationship between meridians and viscera. Specific relationships between acupoints and target organs exist. Stimulating different acupoints on the body surface can help deal with different diseases, especially visceral diseases. In addition, acupoints have a dual function of reflecting and treating visceral diseases. There is no systemic research available on acupoint specificity, despite current knowledge and clinical experiences, which results in a weak foundation for acupuncture theory. This study focuses on the relevance and associations between meridians and viscera. A summary of the mechanisms of acupuncture regulating visceral sensation and mobility and the specific relationships between acupoints and their target organs are presented in this review.

关键词： acupuncture     somite     visceral pain     somato-visceral connection     meridian    

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Clinical acupuncture research in the West

Xianze Meng, Shifen Xu, Lixing Lao

《医学前沿（英文）》 2011年 第5卷 第2期   页码 134-140 doi: 10.1007/s11684-011-0135-9

摘要： In recent years, acupuncture has rapidly become part of mainstream medicine in the West, where new developments in acupuncture clinical research show extensive progress in evaluating the efficacy and safety of the modality in many categories of disease, especially in pain conditions. Although challenges and difficulties remain, the acupuncture research community has matured and its past experience may lead to even better methods and more innovative research.

关键词： acupuncture     clinical research     research methodology     the West    

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Cusp points and assembly changing motions in the PRR-PR-PRR planar parallel manipulator

《机械工程前沿（英文）》 2023年 第18卷 第2期 doi: 10.1007/s11465-022-0743-x

摘要： Most parallel manipulators have multiple solutions to the direct kinematic problem. The ability to perform assembly changing motions has received the attention of a few researchers. Cusp points play an important role in the kinematic behavior. This study investigates the cusp points and assembly changing motions in a two degrees of freedom planar parallel manipulator. The direct kinematic problem of the manipulator yields a quartic polynomial equation. Each root in the equation determines the assembly configuration, and four solutions are obtained for a given set of actuated joint coordinates. By regarding the discriminant of the repeated roots of the quartic equation as an implicit function of two actuated joint coordinates, the direct kinematic singularity loci in the joint space are determined by the implicit function. Cusp points are then obtained by the intersection of a quadratic curve and a cubic curve. Two assembly changing motions by encircling different cusp points are highlighted, for each pair of solutions with the same sign of the determinants of the direct Jacobian matrices.

关键词： planar parallel manipulator     assembly changing motions     cusp points     quartic polynomial     discriminant of repeated roots    

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Prediction of the flash points of alkanes by group bond contribution method using artificial neural networks

PAN Yong, JIANG Juncheng, WANG Zhirong

《化学科学与工程前沿（英文）》 2007年 第1卷 第4期   页码 390-394 doi: 10.1007/s11705-007-0071-z

摘要： A group bond contribution model using artificial neural networks, which had the high ability of nonlinear of prediction, was established to predict the flash points of alkanes. This model contained not only the information of group property but also connectivity in molecules. A set of 16 group bonds were used as input parameters of neural networks to study the correlation of molecular structures with flash points of 44 alkanes. The results showed that the predicted flash points were in good agreement with the experimental data that the absolute mean absolute error was 6.9 K and the absolute mean relative error was 2.29%, which were superior to those of traditional group contribution methods. The method can be used not only to reveal the quantitative correlation between flash points and molecular structures of alkanes but also to predict the flash points of organic compounds for chemical engineering.

关键词： information     nonlinear     quantitative correlation     superior     molecular    

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Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

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《医学前沿（英文）》 2018年 第12卷 第3期   页码 334-339 doi: 10.1007/s11684-017-0539-2

摘要：

Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In China, many PVS patients who were treated with traditional Chinese medicine (TCM) and acupuncture therapy were reported to have regained consciousness. In our department, we have been investigating TCM diagnosis and treatment methods for PVS for many years and have summarized a set of curative programs. Our patient is a male and 5 years and 3 months of age. He had traumatic brain injury and had been unconscious for three months on admission. Considering his condition, we adopted Xingnao Kaiqiao acupuncture, oral Angong Niuhuang Wan, and Xingnaojing intravenous drip. After the 50-day treatment, his health significantly improved and is nearly similar to that of a healthy child, indicating that the treatment is effective for PVS. Therefore, we decided to report the case and treatment methods.

关键词： PVS     stubborn disease     Xingnao Kaiqiao     Angong Niuhuang Wan     TCM     acupuncture    

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Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 141-150 doi: 10.1007/s11684-011-0136-8

摘要： Drug addiction is a chronic brain disorder characterized by withdrawal symptoms that occur during drug abstinence and a high tendency of relapse. Compared with the currently available pharmacological interventions, acupuncture therapy has the potential to help drug addicts stay away from drugs without major adverse side effects. It has taken decades of research to optimize the parameters of electrical acupoint stimulation for detoxification and for relapse prevention, as well as to establish a safe and easy procedure by which drug addicts can use it on themselves. The discovery that acupuncture can trigger the release of opioid substances from the brain in the 1970s provided the inspiration. Following this, basic research on animals made it possible to understand the mechanisms of action and establish the procedure for treating drug addictions. This article reviews the past, present, and foreseeable future regarding the use of acupuncture-related technique for the treatment of opiate addiction from the perspective of translational medicine.

关键词： morphine     dependence     withdrawal     addiction     dynorphins     acupuncture     electroacupuncture     transcutaneous electrical acupoint stimulation (TEAS)     enkephalins     endorphins    

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中国载人航天“飞船起步”的战略思考

赵少奎

《中国工程科学》 2004年 第6卷 第2期   页码 8-12

摘要：

对我国载人航天的概念研究、技术途径论证，以及中国载人航天发展的战略思考和“飞船起步”的决策过程进行了分析与小结,提出了我国发展现代宏大工程应站在国家发展的全局上进行深层次的战略思考。

关键词： 中国载人航天     飞船     技术途径     战略思考    

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标题 作者 时间 类型 操作

A comparative study of electroacupuncture at Zhongliao (BL33) and other acupoints for overactive bladder symptoms

null

期刊论文

Policy entry points for facilitating a transition towards a low-carbon electricity future

期刊论文

Acupuncture for the management of dry eye disease

期刊论文

Effects and mechanisms of acupuncture on women related health

期刊论文

Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking

Xuqiang Wei, Baoyan Liu

期刊论文

Assessment, Development, and Evaluation (GRADE) to the guideline development for clinical practice with acupuncture

null

期刊论文

Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic

期刊论文

Finding buckling points for nonlinear structures by dynamic relaxation scheme

Mohammad REZAIEE-PAJAND, Hossein ESTIRI

期刊论文

Mechanism of acupuncture regulating visceral sensation and mobility

Peijing Rong, Bing Zhu, Yuqing Li, Xinyan Gao, Hui Ben, Yanhua Li, Liang Li, Wei He, Rupeng Liu, Lingling Yu

期刊论文

Clinical acupuncture research in the West

Xianze Meng, Shifen Xu, Lixing Lao

期刊论文

Cusp points and assembly changing motions in the PRR-PR-PRR planar parallel manipulator

期刊论文

Prediction of the flash points of alkanes by group bond contribution method using artificial neural networks

PAN Yong, JIANG Juncheng, WANG Zhirong

期刊论文

Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

null

期刊论文

Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

期刊论文

中国载人航天“飞船起步”的战略思考

赵少奎

期刊论文